MSigDB v2022.1.Mm Release Notes

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Important Notices

This page describes updates made to the Molecular Signatures Database for release 2022.1. This release introduces several major changes to previous conventions. MSigDB is now split into two major divisions; a series of gene set collections that are provided in the namespace of human gene symbols, and a series of gene set collections that are provided in the namespace of mouse gene symbols. As such the versioning convention of MSigDB has changed to adopt the format Year.Release.Species. This initial release in the new format is versioned 2022.1.Hs for the human collections and 2022.1.Mm for the mouse collections. Likewise, CHIP files have been updated to reflect this convention, as well as the specific series of collections (i.e. human or mouse) that they are targeted towards.

Note that in order to access the MSigBD mouse collections through the GSEA UI, the latest version of GSEA (4.3.0) is required.

MSigDB v2022.1 is based on gene annotation data from Ensembl Release 107 (Jul 2022).

Initial Release of Mouse Collections (MSigDB v2022.1.Mm)

The initial release of the MSigDB Mouse Collections contains the following 6 collections, with some collection numbers reserved for future development. Please see the Collection Details Page for collection-specific general information.

CHIP file release

• MSigDB 2022.1.Mm gene annotations and gene mapping CHIP files are being provided utilizing data from Ensembl 107.
• Gene orthology annotations for mapping human and rat genes to their best match mouse orthologs are being provided utilizing information from Alliance of Genome Resources orthology database release 5.2.1 (2022-07-15)