Molecular Signatures Database v5.2


The Molecular Signatures Database (MSigDB) is a collection of annotated gene sets for use with GSEA software. From this web site, you can

  • Search for gene sets by keyword.
  • Browse gene sets by name or collection.
  • Examine a gene set and its annotations. See, for example, the GO_NOTCH_SIGNALING_PATHWAY gene set page.
  • Download gene sets.
  • Investigate gene sets:
    • Compute overlaps between your gene set and gene sets in MSigDB.
    • Categorize members of a gene set by gene families.
    • View the expression profile of a gene set in any of the three provided public expression compendia.


Please register to download the GSEA software and view the MSigDB gene sets. After registering, you can log in at any time using your email address. Registration is free. Its only purpose is to help us track usage for reports to our funding agencies.

Current Version

MSigDB database v5.2 updated October 2016. Release notes.
GSEA/MSigDB web site v5.0 released March 2015


The MSigDB is maintained by the GSEA team with the support of our MSigDB Scientific Advisory Board. We also welcome and appreciate contributions to this shared resource and encourage users to submit their gene sets to Our thanks to our many contributors.

Funded by: National Cancer Institute, National Institutes of Health, National Institute of General Medical Sciences.


The MSigDB gene sets are divided into 8 major collections:

Citing the MSigDB

To cite your use of the Molecular Signatures Database (MSigDB), please reference Subramanian, Tamayo, et al. (2005, PNAS 102, 15545-15550) and also the source for the gene set as listed on the gene set page.