Gene Set: ACEVEDO_FGFR1_TARGETS_IN_PROSTATE_CANCER_MODEL_UP

Standard name ACEVEDO_FGFR1_TARGETS_IN_PROSTATE_CANCER_MODEL_UP
Systematic name M2570
Brief description Genes up-regulated during prostate cancer progression in the JOCK1 model due to inducible activation of FGFR1 [GeneID=2260] gene in prostate.
Full description or abstract Fibroblast Growth Factor Receptor-1 (FGFR1) is commonly overexpressed in advanced prostate cancer (PCa). To investigate causality, we utilized an inducible FGFR1 (iFGFR1) prostate mouse model. Activation of iFGFR1 with chemical inducers of dimerization (CID) led to highly synchronous, step-wise progression to adenocarcinoma that is linked to an epithelial-to-mesenchymal transition (EMT). iFGFR1 inactivation by CID withdrawal led to full reversion of prostatic intraepithelial neoplasia, whereas PCa lesions became iFGFR1-independent. Gene expression profiling at distinct stages of tumor progression revealed an increase in EMT-associated Sox9 and changes in the Wnt signaling pathway, including Fzd4, which was validated in human PCa. The iFGFR1 model clearly implicates FGFR1 in PCa progression and demonstrates how CID-inducible models can help evaluate candidate molecules in tumor progression and maintenance.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 18068632   Authors: Acevedo VD,Gangula RD,Freeman KW,Li R,Zhang Y,Wang F,Ayala GE,Peterson LE,Ittmann M,Spencer DM
Exact source Table 1S: Avg. fold change > 1
Related gene sets (show 1 additional gene sets from the source publication)

(show 59 gene sets from the same authors)
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Organism Mus musculus
Contributed by Yujin Hoshida (Broad Institute)
Source platform UnigeneIdentifiers
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Compendia expression profiles Human tissue compendium (Novartis)
NCI-60 cell lines (National Cancer Institute)
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Version history 3.1: First introduced

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