Gene Set: BAKER_HEMATOPOIESIS_STAT3_TARGETS

Standard name BAKER_HEMATOPOIESIS_STAT3_TARGETS
Systematic name M1163
Brief description STAT3 [GeneID=6774] targets in hematopoietic signaling.
Full description or abstract Hematopoiesis is the cumulative result of intricately regulated signaling pathways that are mediated by cytokines and their receptors. Proper culmination of these diverse pathways forms the basis for an orderly generation of different cell types. Recent studies conducted over the past 10-15 years have revealed that hematopoietic cytokine receptor signaling is largely mediated by a family of tyrosine kinases termed Janus kinases (JAKs) and their downstream transcription factors termed STATs (signal transducers and activators of transcription). Aberration in these pathways, such as that caused by the recently identified JAK2V617F mutation, is an underlying cause for diseases such as leukemias and other myeloproliferative disorders. This recent discovery, when coupled with the fact that STATs are activated by oncoproteins such as BCR-ABL, underscores the importance of the JAK-STAT pathway in both normal cellular development and disease states.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 17934481   Authors: Baker SJ,Rane SG,Reddy EP
Exact source Table 2: STAT3
Related gene sets (show 2 additional gene sets from the source publication)

(show 4 gene sets from the same authors)
External links  
Organism Mus musculus
Contributed by Arthur Liberzon (Broad Institute)
Source platform MOUSE_GENE_SYMBOL
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Compendia expression profiles Human tissue compendium (Novartis)
NCI-60 cell lines (National Cancer Institute)
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Version history 3.1: First introduced

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