Systematic name M9070
Brief description Transcription factor CREB and its extracellular signals
Full description or abstract The transcription factor CREB binds the cyclic AMP response element (CRE) and activates transcription in response to a variety of extracellular signals including neurotransmitters, hormones, membrane depolarization, and growth and neurotrophic factors. Protein kinase A and the calmodulin-dependent protein kinases CaMKII stimulate CREB phosphorylation at Ser133, a key regulatory site controlling transcriptional activity. Growth and neurotrophic factors also stimulate CREB phosphorylation at Ser133. Phosphorylation occurs at Ser133 via p44/42 MAP Kinase and p90RSK and also via p38 MAP Kinase and MSK1. CREB exhibit deficiencies in spatial learning tasks, while flies overexpressing or lacking CREB show enhanced or diminished learning, respectively.
Collection C2: curated gene sets
      CP:BIOCARTA: BioCarta gene sets
Source publication  
Exact source  
Related gene sets  
External links
Organism Homo sapiens
Contributed by BioCarta
Source platform EntrezGeneIds
Dataset references  
Download gene set format: grp | text | gmt | gmx | xml
Compute overlaps (show collections to investigate for overlap with this gene set)
Compendia expression profiles Human tissue compendium (Novartis)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 27 genes
Gene families Categorize these 27 genes by gene family
Show members (show 27 members mapped to 27 genes)
Version history  

See MSigDB license terms here. Please note that certain gene sets have special access terms.