Gene Set: BIOCARTA_STEM_PATHWAY

Standard name BIOCARTA_STEM_PATHWAY
Systematic name M5298
Brief description Regulation of hematopoiesis by cytokines
Full description or abstract The process of hematopoesis is regulated by various cytokines. The combination of cytokines stimulates the proliferation and/or differentiation of the various hematopoietic cell types. Bone marrow stromal cells are the major source of hematopoietic cytokines in the non-infecteous state. In the presence of infection, cytokines produced by activated macrophages and TH cells induce hematopoietic activity. The induction by cytokines results in rapid expansion of the population of white blood cells to fight infection. The specific cytokines that affect a step of cell differentiation are placed adjacent to the arrow representing that step. Lines with '?' indicate likely, but still hypothetical pathways.
Collection C2: curated gene sets
      CP:BIOCARTA: BioCarta gene sets
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External links http://cgap.nci.nih.gov/Pathways/BioCarta/h_stemPathway
http://cgap.nci.nih.gov/Genes/PathGeneQuery?PAGE=1&ORG=Hs&PATH=h_stemPathway
Organism Homo sapiens
Contributed by BioCarta
Source platform EntrezGeneIds
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Compendia expression profiles Human tissue compendium (Novartis)
NCI-60 cell lines (National Cancer Institute)
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