Gene Set: BIOCARTA_TCAPOPTOSIS_PATHWAY

Standard name BIOCARTA_TCAPOPTOSIS_PATHWAY
Systematic name M16519
Brief description HIV Induced T Cell Apoptosis
Full description or abstract HIV infection is associated with immunosuppression caused by a dramatic reduction in the helper T cell population. The loss of helper T cells may be caused by HIV-induced apoptosis of both infected and uninfected helper T cells. HIV uses the CCR5 chemokine receptor as a coreceptor for macrophage cell entry and upregulates fas-ligand on these cells. CD4 on helper T cells is essential for viral cell entry and infection. Cross-linking of CD4 on the T cell surface may be involved in upregulation of Fas and sensitization of T cells to apoptosis induced by the Fas/Fas-ligand interaction.
Collection C2: curated gene sets
      CP:BIOCARTA: BioCarta gene sets
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External links http://cgap.nci.nih.gov/Pathways/BioCarta/h_tcapoptosisPathway
http://cgap.nci.nih.gov/Genes/PathGeneQuery?PAGE=1&ORG=Hs&PATH=h_tcapoptosisPathway
Organism Homo sapiens
Contributed by BioCarta
Source platform EntrezGeneIds
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Compendia expression profiles Human tissue compendium (Novartis)
NCI-60 cell lines (National Cancer Institute)
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