Gene Set: BIOCARTA_TNFR1_PATHWAY

Standard name BIOCARTA_TNFR1_PATHWAY
Systematic name M3618
Brief description TNFR1 Signaling Pathway
Full description or abstract TNFR1 (a.k.a. p55, CD120a) is the receptor for TNF(alpha) and also will bind TNF(beta). Upon binding TNF(alpha) a TNFR1+ cell is triggered to undergo apoptosis. This critical regulatory process is accomplished by activating the proteolytic caspase cascade that results in the degradation of many critical cellular proteins.
Collection C2: curated gene sets
      CP:BIOCARTA: BioCarta gene sets
Source publication  
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External links http://cgap.nci.nih.gov/Pathways/BioCarta/h_tnfr1Pathway
http://cgap.nci.nih.gov/Genes/PathGeneQuery?PAGE=1&ORG=Hs&PATH=h_tnfr1Pathway
Organism Homo sapiens
Contributed by BioCarta
Source platform EntrezGeneIds
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Compendia expression profiles Human tissue compendium (Novartis)
NCI-60 cell lines (National Cancer Institute)
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