Gene Set: BONE_REMODELING

Standard name BONE_REMODELING
Systematic name M2217
Brief description Genes annotated by the GO term GO:0046849. The continuous turnover of bone matrix and mineral that involves first, an increase in resorption (osteoclastic activity) and later, reactive bone formation (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium homeostasis. An imbalance in the regulation of bone resorption and bone formation results in many of the metabolic bone diseases, such as osteoporosis.
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Collection ARCHIVED: Archived Founder gene sets that are referenced by current Hallmarks.
      C5_BP: Archived GO biological process
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External links http://amigo.geneontology.org/amigo/term/GO:0046849
Organism Homo sapiens
Contributed by Gene Ontology (Gene Ontology Consortium)
Source platform HUMAN_GENE_SYMBOL
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Version history 5.2: Archived

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