Gene Set: BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS

Standard name BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS
Systematic name M2388
Brief description Transcripts in hematopoietic stem cells (HSC) which are trans-regulated (i.e., modulated by a QTL (quantitative trait locus) not in a close proximity to the gene).
Full description or abstract We combined large-scale mRNA expression analysis and gene mapping to identify genes and loci that control hematopoietic stem cell (HSC) function. We measured mRNA expression levels in purified HSCs isolated from a panel of densely genotyped recombinant inbred mouse strains. We mapped quantitative trait loci (QTLs) associated with variation in expression of thousands of transcripts. By comparing the physical transcript position with the location of the controlling QTL, we identified polymorphic cis-acting stem cell genes. We also identified multiple trans-acting control loci that modify expression of large numbers of genes. These groups of coregulated transcripts identify pathways that specify variation in stem cells. We illustrate this concept with the identification of candidate genes involved with HSC turnover. We compared expression QTLs in HSCs and brain from the same mice and identified both shared and tissue-specific QTLs. Our data are accessible through WebQTL, a web-based interface that allows custom genetic linkage analysis and identification of coregulated transcripts.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 15711547   Authors: Bystrykh L,Weersing E,Dontje B,Sutton S,Pletcher MT,Wiltshire T,Su AI,Vellenga E,Wang J,Manly KF,Lu L,Chesler EJ,Alberts R,Jansen RC,Williams RW,Cooke MP,de Haan G
Exact source Table 3S
Related gene sets (show 9 additional gene sets from the source publication)

(show 37 gene sets from the same authors)
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Organism Mus musculus
Contributed by Jean Junior (Broad Institute)
Source platform MG_U74Av2
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Compendia expression profiles Human tissue compendium (Novartis)
NCI-60 cell lines (National Cancer Institute)
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Version history 3.0: Renamed from BYSTRYKH_HSC_TRANS_REGULATED_QTL

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