Gene Set: CAIRO_HEPATOBLASTOMA_CLASSES_UP

Standard name CAIRO_HEPATOBLASTOMA_CLASSES_UP
Systematic name M4772
Brief description Genes up-regulated in robust Cluster 2 (rC2) of hepatoblastoma samples compared to those in the robust Cluster 1 (rC1).
Full description or abstract Hepatoblastoma, the most common pediatric liver cancer, is tightly linked to excessive Wnt/beta-catenin signaling. Here, we used microarray analysis to identify two tumor subclasses resembling distinct phases of liver development and a discriminating 16-gene signature. beta-catenin activated different transcriptional programs in the two tumor types, with distinctive expression of hepatic stem/progenitor markers in immature tumors. This highly proliferating subclass was typified by gains of chromosomes 8q and 2p and upregulated Myc signaling. Myc-induced hepatoblastoma-like tumors in mice strikingly resembled the human immature subtype, and Myc downregulation in hepatoblastoma cells impaired tumorigenesis in vivo. Remarkably, the 16-gene signature discriminated invasive and metastatic hepatoblastomas and predicted prognosis with high accuracy.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 19061838   Authors: Cairo S,Armengol C,Reyniès De A,Wei Y,Thomas E,Renard CA,Goga A,Balakrishnan A,Semeraro M,Gresh L,Pontoglio M,Strick-Marchand H,Levillayer F,Nouet Y,Rickman D,Gauthier F,Branchereau S,Brugières L,Laithier V,Bouvier R,Boman F,Basso G,Michiels JF,Hofman P,Arbez-Gindre F,Jouan H,Rousselet-Chapeau MC,Berrebi D,Marcellin L,Plenat F,Zachar D,Joubert M,Selves J,Pasquier D,Bioulac-Sage P,Grotzer M,Childs M,Fabre M,Buendia MA
Exact source Table 7S: Fold change rC2/rC1 >= 1.3
Related gene sets (show 6 additional gene sets from the source publication)

(show 83 gene sets from the same authors)
External links  
Organism Homo sapiens
Contributed by Arthur Liberzon (Broad Institute)
Source platform HG-U133A
Dataset references (show 3 datasets)
Download gene set format: grp | text | gmt | gmx | xml
Compute overlaps (show collections to investigate for overlap with this gene set)
Compendia expression profiles Human tissue compendium (Novartis)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 605 genes
Gene families Categorize these 605 genes by gene family
Show members (show 733 members mapped to 605 genes)
Version history 3.0: First introduced

See MSigDB license terms here. Please note that certain gene sets have special access terms.