Gene Set: CHEN_ETV5_TARGETS_TESTIS

Standard name CHEN_ETV5_TARGETS_TESTIS
Systematic name M1664
Brief description Genes down-regulated in testis from 4 week old ETV5 [GeneID=2119] knockout mice.
Full description or abstract Division of spermatogonial stem cells produces daughter cells that either maintain their stem cell identity or undergo differentiation to form mature sperm. The Sertoli cell, the only somatic cell within seminiferous tubules, provides the stem cell niche through physical support and expression of surface proteins and soluble factors. Here we show that the Ets related molecule (ERM) is expressed exclusively within Sertoli cells in the testis and is required for spermatogonial stem cell self-renewal. Mice with targeted disruption of ERM have a loss of maintenance of spermatogonial stem cell self-renewal without a block in normal spermatogenic differentiation and thus have progressive germ-cell depletion and a Sertoli-cell-only syndrome. Microarray analysis of primary Sertoli cells from ERM-deficient mice showed alterations in secreted factors known to regulate the haematopoietic stem cell niche. These results identify a new function for the Ets family transcription factors in spermatogenesis and provide an example of transcriptional control of a vertebrate stem cell niche.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 16107850   Authors: Chen C,Ouyang W,Grigura V,Zhou Q,Carnes K,Lim H,Zhao GQ,Arber S,Kurpios N,Murphy TL,Cheng AM,Hassell JA,Chandrashekar V,Hofmann MC,Hess RA,Murphy KM
Exact source Table 1S
Related gene sets (show 1 additional gene sets from the source publication)

(show 137 gene sets from the same authors)
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Organism Mus musculus
Contributed by John Newman (University of Washington)
Source platform SEQ_ACCESSION
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Compendia expression profiles Human tissue compendium (Novartis)
NCI-60 cell lines (National Cancer Institute)
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Version history 3.1: First introduced

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