Systematic name M11701
Brief description Selected genes up-regulated during invasion of lymphatic vessels during metastasis.
Full description or abstract Invasion of lymphatic vessels is a key step in the metastasis of primary tumors to draining lymph nodes. Although the process is enhanced by tumor lymphangiogenesis, it is unclear whether this is a consequence of increased lymphatic vessel number, altered lymphatic vessel properties, or both. Here we have addressed the question by comparing the RNA profiles of primary lymphatic endothelial cells (LEC) isolated from the vasculature of normal tissue and from highly metastatic T-241/vascular endothelial growth factor (VEGF)-C fibrosarcomas implanted in C57BL/6 mice. Our findings reveal significant differences in expression of some 792 genes (i.e., >or=2-fold up- or down-regulated, P
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 18794116   Authors: Clasper S,Royston D,Baban D,Cao Y,Ewers S,Butz S,Vestweber D,Jackson DG
Exact source Table 1: fold change > 0
Related gene sets (show 1 additional gene sets from the source publication)

(show 11 gene sets from the same authors)
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Organism Mus musculus
Contributed by Jessica Robertson (Broad Institute)
Source platform Mouse430_2
Dataset references (show 1 datasets)
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Compendia expression profiles Human tissue compendium (Novartis)
NCI-60 cell lines (National Cancer Institute)
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Version history 3.0: First introduced

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