Gene Set: CORDENONSI_YAP_CONSERVED_SIGNATURE

Standard name CORDENONSI_YAP_CONSERVED_SIGNATURE
Systematic name M2871
Brief description YAP conserved signature.
Full description or abstract Cancer stem cells (CSCs) are proposed to drive tumor initiation and progression. Yet, our understanding of the cellular and molecular mechanisms that underlie CSC properties is limited. Here we show that the activity of TAZ, a transducer of the Hippo pathway, is required to sustain self-renewal and tumor-initiation capacities in breast CSCs. TAZ protein levels and activity are elevated in prospective CSCs and in poorly differentiated human tumors and have prognostic value. Gain of TAZ endows self-renewal capacity to non-CSCs. In epithelial cells, TAZ forms a complex with the cell-polarity determinant Scribble, and loss of Scribble--or induction of the epithelial-mesenchymal transition (EMT)--disrupts the inhibitory association of TAZ with the core Hippo kinases MST and LATS. This study links the CSC concept to the Hippo pathway in breast cancer and reveals a mechanistic basis of the control of Hippo kinases by cell polarity
Collection C6: oncogenic signatures
Source publication Pubmed 22078877   Authors: Cordenonsi M,Zanconato F,Azzolin L,Forcato M,Rosato A,Frasson C,Inui M,Montagner M,Parenti AR,Poletti A,Daidone MG,Dupont S,Basso G,Bicciato S,Piccolo S
Exact source Table 3S
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Organism Homo sapiens
Contributed by Pablo Tamayo (Broad Institute)
Source platform HG-U133A
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Compendia expression profiles Human tissue compendium (Novartis)
NCI-60 cell lines (National Cancer Institute)
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