Gene Set: CRX_NRL_DN.V1_DN

Standard name CRX_NRL_DN.V1_DN
Systematic name M2794
Brief description Genes down-regulated in retina cells from CRX and NRL [GeneID=1406] [GeneID=4901] double knockout mice.
Full description or abstract Complete microarray datasets for wild-type vs. Crx-/-; Nrl-/- comparison at P21 are in Supplementary Table S6. This table contains the full microarray datasets from nine microarray hybridizations (three biological replicates each from wild-type (C57BL/6), wild-type (129S6/SvEv) and Crx-/-; Nrl-/- retinas at P21). Since Crx-/-; Nrl-/- is on a mixed 129 X B6 background, we present comparisons between both of the individual wild-type mutant backgrounds (as data from the mixed control background were not available). The data from each of the individual microarray experiments are labeled with the following prefixes:Crx-mut_#1i etc.,B6-wt-P21-#1i etc. and129-wt-P21-#1i etc.
Collection C6: oncogenic signatures
Source publication Pubmed 17653270   Authors: Hsiau TH,Diaconu C,Myers CA,Lee J,Cepko CL,Corbo JC
Exact source Crx -/- & Nrl-/- mouse retina cells vs Controls; top 150 genes (diff. of means)
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(show 78 gene sets from the same authors)
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Organism Mus musculus
Contributed by Pablo Tamayo (Broad Institute)
Source platform HUMAN_GENE_SYMBOL
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Compendia expression profiles Human tissue compendium (Novartis)
NCI-60 cell lines (National Cancer Institute)
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