Gene Set: DER_IFN_GAMMA_RESPONSE_UP

Standard name DER_IFN_GAMMA_RESPONSE_UP
Systematic name M15615
Brief description Genes up-regulated in HT1080 (fibrosarcoma) cells by treatment with interferon gamma for 6 h.
Full description or abstract The pleiotropic activities of interferons (IFNs) are mediated primarily through the transcriptional regulation of many downstream effector genes. The mRNA profiles from IFN-alpha, -beta, or -gamma treatments of the human fibrosarcoma cell line, HT1080, were determined by using oligonucleotide arrays with probe sets corresponding to more than 6,800 human genes. Among these were transcripts for known IFN-stimulated genes (ISGs), the expression of which were consistent with previous studies in which the particular ISG was characterized as responsive to either Type I (alpha, beta) or Type II (gamma) IFNs, or both. Importantly, many novel IFN-stimulated genes were identified that were diverse in their known biological functions. For instance, several novel ISGs were identified that are implicated in apoptosis (including RAP46/Bag-1, phospholipid scramblase, and hypoxia inducible factor-1alpha). Furthermore, several IFN-repressed genes also were identified. These results demonstrate the usefulness of oligonucleotide arrays in monitoring mammalian gene expression on a broad and unprecedented scale. In particular, these findings provide insights into the basic mechanisms of IFN actions and ultimately may contribute to better therapeutic uses for IFNs.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 9861020   Authors: Der SD,Zhou A,Williams BR,Silverman RH
Exact source Table 2: IFN gamma
Related gene sets (show 5 additional gene sets from the source publication)

(show 6 gene sets from the same authors)
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Organism Homo sapiens
Contributed by Yujin Hoshida (Broad Institute)
Source platform Hu6800
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Compendia expression profiles Human tissue compendium (Novartis)
NCI-60 cell lines (National Cancer Institute)
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Version history 3.0: Renamed from DER_IFNG_UP

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