Systematic name M798
Brief description Genes up-regulated in basal radial glia (bRG) relative to apical radial glia (aRG), and up-regulated in both aRG and bRG relative to neurons.
Full description or abstract Evolutionary expansion of the human neocortex reflects increased amplification of basal progenitors in the subventricular zone, producing more neurons during fetal corticogenesis. In this work, we analyze the transcriptomes of distinct progenitor subpopulations isolated by a cell polarity-based approach from developing mouse and human neocortex. We identify 56 genes preferentially expressed in human apical and basal radial glia that lack mouse orthologs. Among these, ARHGAP11B has the highest degree of radial glia-specific expression. ARHGAP11B arose from partial duplication of ARHGAP11A (which encodes a Rho guanosine triphosphatase-activating protein) on the human lineage after separation from the chimpanzee lineage. Expression of ARHGAP11B in embryonic mouse neocortex promotes basal progenitor generation and self-renewal and can increase cortical plate area and induce gyrification. Hence, ARHGAP11B may have contributed to evolutionary expansion of human neocortex.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 25721503   Authors: Florio M,Albert M,Taverna E,Namba T,Brandl H,Lewitus E,Haffner C,Sykes A,Wong FK,Peters J,Guhr E,Klemroth S,Prüfer K,Kelso J,Naumann R,Nüsslein I,Dahl A,Lachmann R,Pääbo S,Huttner WB
Exact source Table 2S: bRG?aRG>N (394)
Related gene sets (show 2 additional gene sets from the source publication)

(show 13 gene sets from the same authors)
External links  
Organism Homo sapiens
Contributed by Arthur Liberzon (Broad Institute)
Source platform EnsemblGeneIds
Dataset references (show 1 datasets)
Download gene set format: grp | text | gmt | gmx | xml
Compute overlaps (show collections to investigate for overlap with this gene set)
Compendia expression profiles Human tissue compendium (Novartis)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 380 genes
Gene families Categorize these 380 genes by gene family
Show members (show 394 members mapped to 380 genes)
Version history 6.2: First introduced

See MSigDB license terms here. Please note that certain gene sets have special access terms.