Gene Set: GEISS_RESPONSE_TO_DSRNA_DN

Standard name GEISS_RESPONSE_TO_DSRNA_DN
Systematic name M19944
Brief description Genes down-pregulated by dsRNA in GRE cells (glioma; no interferon system).
Full description or abstract Double-stranded (ds) RNA, a common component of virus-infected cells, is a potent inducer of the type I interferon and other cellular genes. For identifying the full repertoire of human dsRNA-regulated genes, a cDNA microarray hybridization screening was conducted using mRNA from dsRNA-treated GRE cells. Because these cells lack all type I interferon genes, the possibility of gene induction by autocrine actions of interferon was eliminated. Our screen identified 175 dsRNA-stimulated genes (DSG) and 95 dsRNA-repressed genes. A subset of the DSGs was also induced by different inflammatory cytokines and viruses demonstrating interconnections among disparate signaling pathways. Functionally, the DSGs encode proteins involved in signaling, apoptosis, RNA synthesis, protein synthesis and processing, cell metabolism, transport, and structure. Induction of such a diverse family of genes by dsRNA has major implications in host-virus interactions and in the use of RNA(i) technology for functional ablation of specific genes.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 11487589   Authors: Geiss G,Jin G,Guo J,Bumgarner R,Katze MG,Sen GC
Exact source Table 2
Related gene sets (show 1 additional gene sets from the source publication)

(show 18 gene sets from the same authors)
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Organism Homo sapiens
Contributed by John Newman (University of Washington)
Source platform HUMAN_GENE_SYMBOL
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Compendia expression profiles Human tissue compendium (Novartis)
NCI-60 cell lines (National Cancer Institute)
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Version history 3.0: Renamed from DSRNA_DN

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