Gene Set: GO_CANONICAL_WNT_SIGNALING_PATHWAY

Standard name GO_CANONICAL_WNT_SIGNALING_PATHWAY
Systematic name M12752
Brief description The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes.
Full description or abstract  
Collection C5: GO gene sets
      BP: GO biological process
Source publication  
Exact source GO:0060070
Related gene sets  
External links http://amigo.geneontology.org/amigo/term/GO:0060070
Organism Homo sapiens
Contributed by Gene Ontology (Gene Ontology Consortium)
Source platform EntrezGeneIds
Dataset references  
Download gene set format: grp | text | gmt | gmx | xml
Compute overlaps (show collections to investigate for overlap with this gene set)
Compendia expression profiles Human tissue compendium (Novartis)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 95 genes
Gene families Categorize these 95 genes by gene family
Show members (show 95 members mapped to 95 genes)
Version history 5.2: First introduced

See MSigDB license terms here. Please note that certain gene sets have special access terms.