Gene Set: GO_IKAPPAB_KINASE_COMPLEX

Standard name GO_IKAPPAB_KINASE_COMPLEX
Systematic name M17634
Brief description A trimeric protein complex that phosphorylates inhibitory-kappaB (I-kappaB) proteins. The complex is composed of two kinase subunits (alpha and beta) and a regulatory gamma subunit (also called NEMO). In a resting state, NF-kappaB dimers are bound to inhibitory IKB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.
Full description or abstract  
Collection C5: GO gene sets
      CC: GO cellular component
Source publication  
Exact source GO:0008385
Related gene sets  
External links http://amigo.geneontology.org/amigo/term/GO:0008385
Organism Homo sapiens
Contributed by Gene Ontology (Gene Ontology Consortium)
Source platform EntrezGeneIds
Dataset references  
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Compendia expression profiles Human tissue compendium (Novartis)
NCI-60 cell lines (National Cancer Institute)
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Version history 5.2: First introduced

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