Gene Set: GO_IRE1_MEDIATED_UNFOLDED_PROTEIN_RESPONSE

Standard name GO_IRE1_MEDIATED_UNFOLDED_PROTEIN_RESPONSE
Systematic name M10426
Brief description A series of molecular signals mediated by the endoplasmic reticulum stress sensor IRE1 (Inositol-requiring transmembrane kinase/endonuclease). Begins with activation of IRE1 in response to endoplasmic reticulum (ER) stress, and ends with regulation of a downstream cellular process, e.g. transcription. One target of activated IRE1 is the transcription factor HAC1 in yeast, or XBP1 in mammals; IRE1 cleaves an intron of a mRNA coding for HAC1/XBP1 to generate an activated HAC1/XBP1 transcription factor, which controls the up regulation of UPR-related genes. At least in mammals, IRE1 can also signal through additional intracellular pathways including JNK and NF-kappaB.
Full description or abstract  
Collection C5: GO gene sets
      BP: GO biological process
Source publication  
Exact source GO:0036498
Related gene sets  
External links http://amigo.geneontology.org/amigo/term/GO:0036498
Organism Homo sapiens
Contributed by Gene Ontology (Gene Ontology Consortium)
Source platform EntrezGeneIds
Dataset references  
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Compendia expression profiles Human tissue compendium (Novartis)
NCI-60 cell lines (National Cancer Institute)
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Version history 5.2: First introduced

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