Gene Set: HOFFMANN_LARGE_TO_SMALL_PRE_BII_LYMPHOCYTE_UP

Standard name HOFFMANN_LARGE_TO_SMALL_PRE_BII_LYMPHOCYTE_UP
Systematic name M5588
Brief description Genes up-regulated during differentiation from large pre-BII to small pre-BII lymphocyte.
Full description or abstract Gene expression profiles of five consecutive stages of mouse B cell development were generated with high-density oligonucleotide arrays from as few as 2 x 10(4) ex vivo isolated and flow-cytometrically purified cells. Between 2.8% and 6.8% of all genes change on differentiation from one cellular stage to the next by at least twofold. The entire pathway involves differential expression of 10.7% of all genes. Previously known expression patterns of 15 genes (like surrogate light chain, RAG-1/2, MHC class II, mel-14 antigen) are confirmed. The gene expression patterns of the proliferating pre-BI and large pre-BII cells on the one hand, and the resting immature and mature B cells on the other hand, are most similar to each other. Small pre-BII cells display a pattern that is transitional between these two groups. Most of the genes expressed in early precursors are involved in general processes, like protein folding or cell cycle regulation, whereas more mature precursors express genes involved in more specific molecular programs (cell surface receptors, secreted factors, and adhesion molecules, among others). Between 19 and 139 genes share a given expression pattern. Combining knowledge about gene function and expression pattern allows identification of novel candidate genes potentially involved in self-maintenance of pre-BI cells, allelic exclusion and pre-B cell receptor signaling in large pre BII cells, cell-cycle arrest of small pre-BII cells, propensity toward apoptosis or anergization in immature B cells, propensity toward cell division and activation in mature B cells, and stage-specific interactions with stromal cells in the bone marrow.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 11779835   Authors: Hoffmann R,Seidl T,Neeb M,Rolink A,Melchers F
Exact source Table 2S: CHGF_LAR_SMA>=4
Related gene sets (show 7 additional gene sets from the source publication)

(show 29 gene sets from the same authors)
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Organism Mus musculus
Contributed by Arthur Liberzon (Broad Institute)
Source platform Mu11KsubA
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Compendia expression profiles Human tissue compendium (Novartis)
NCI-60 cell lines (National Cancer Institute)
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