Gene Set: HOLLEMAN_ASPARAGINASE_RESISTANCE_B_ALL_DN

Standard name HOLLEMAN_ASPARAGINASE_RESISTANCE_B_ALL_DN
Systematic name M2554
Brief description Genes distinguishing asparaginase resistant and sensitive B-lineage ALL; here - genes down-regulated in the drug resistant samples.
Full description or abstract Childhood acute lymphoblastic leukemia (ALL) is curable with chemotherapy in approximately 80 percent of patients. However, the cause of treatment failure in the remaining 20 percent of patients is largely unknown.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 15295046   Authors: Holleman A,Cheok MH,den Boer ML,Yang W,Veerman AJ,Kazemier KM,Pei D,Cheng C,Pui CH,Relling MV,Janka-Schaub GE,Pieters R,Evans WE
Exact source Fig. 7S: R/S ratio < 1
Related gene sets (show 15 additional gene sets from the source publication)

(show 28 gene sets from the same authors)
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Organism Homo sapiens
Contributed by Arthur Liberzon (Broad Institute)
Source platform HG-U133A
Dataset references (show 1 datasets)
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Compendia expression profiles Human tissue compendium (Novartis)
NCI-60 cell lines (National Cancer Institute)
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Version history 3.1: First introduced

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