Gene Set: HUMMEL_BURKITTS_LYMPHOMA_DN

Standard name HUMMEL_BURKITTS_LYMPHOMA_DN
Systematic name M18181
Brief description Down-regulated genes constituting the molecular signature of Burkitt 's lymphoma.
Full description or abstract BACKGROUND: The distinction between Burkitt's lymphoma and diffuse large-B-cell lymphoma is unclear. We used transcriptional and genomic profiling to define Burkitt's lymphoma more precisely and to distinguish subgroups in other types of mature aggressive B-cell lymphomas. METHODS: We performed gene-expression profiling using Affymetrix U133A GeneChips with RNA from 220 mature aggressive B-cell lymphomas, including a core group of 8 Burkitt's lymphomas that met all World Health Organization (WHO) criteria. A molecular signature for Burkitt's lymphoma was generated, and chromosomal abnormalities were detected with interphase fluorescence in situ hybridization and array-based comparative genomic hybridization. RESULTS: We used the molecular signature for Burkitt's lymphoma to identify 44 cases: 11 had the morphologic features of diffuse large-B-cell lymphomas, 4 were unclassifiable mature aggressive B-cell lymphomas, and 29 had a classic or atypical Burkitt's morphologic appearance. Also, five did not have a detectable IG-myc Burkitt's translocation, whereas the others contained an IG-myc fusion, mostly in simple karyotypes. Of the 176 lymphomas without the molecular signature for Burkitt's lymphoma, 155 were diffuse large-B-cell lymphomas. Of these 155 cases, 21 percent had a chromosomal breakpoint at the myc locus associated with complex chromosomal changes and an unfavorable clinical course. CONCLUSIONS: Our molecular definition of Burkitt's lymphoma clarifies and extends the spectrum of the WHO criteria for Burkitt's lymphoma. In mature aggressive B-cell lymphomas without a gene signature for Burkitt's lymphoma, chromosomal breakpoints at the myc locus were associated with an adverse clinical outcome.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 16760442   Authors: Hummel M,Bentink S,Berger H,Klapper W,Wessendorf S,Barth TF,Bernd HW,Cogliatti SB,Dierlamm J,Feller AC,Hansmann ML,Haralambieva E,Harder L,Hasenclever D,Kühn M,Lenze D,Lichter P,Martin-Subero JI,Möller P,Müller-Hermelink HK,Ott G,Parwaresch RM,Pott C,Rosenwald A,Rosolowski M,Schwaenen C,Stürzenhofecker B,Szczepanowski M,Trautmann H,Wacker HH,Spang R,Loeffler M,Trümper L,Stein H,Siebert R,LastName M
Exact source Table 5.3.2S
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Organism Homo sapiens
Contributed by Arthur Liberzon (Broad Institute)
Source platform HG-U133A
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Compendia expression profiles Human tissue compendium (Novartis)
NCI-60 cell lines (National Cancer Institute)
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Version history 3.0: First introduced

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