Gene Set: KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY

Standard name KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY
Systematic name M5436
Brief description B cell receptor signaling pathway
Full description or abstract B cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The B cell receptor (BCR) is an integral membrane protein complex that is composed of two immunoglobulin (Ig) heavy chains, two Ig light chains and two heterodimers of Ig-alpha and Ig-beta. After BCR ligation by antigen, three main protein tyrosine kinases (PTKs) -the SRC-family kinase LYN, SYK and the TEC-family kinase BTK- are activated. Phosphatidylinositol 3-kinase (PI3K) and phospholipase C-gamma 2 (PLC-gamma 2) are important downstream effectors of BCR signalling. This signalling ultimately results in the expression of immediate early genes that further activate the expression of other genes involved in B cell proliferation, differentiation and Ig production as well as other processes.
Collection C2: curated gene sets
      CP:KEGG: KEGG gene sets
Source publication  
Exact source hsa04662
Related gene sets  
External links http://www.genome.jp/kegg/pathway/hsa/hsa04662.html
Organism Homo sapiens
Contributed by KEGG (Kyoto Encyclopedia of Genes and Genomes)
Source platform EntrezGeneIds
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Compendia expression profiles Human tissue compendium (Novartis)
NCI-60 cell lines (National Cancer Institute)
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