Gene Set: KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION

Standard name KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION
Systematic name M3578
Brief description Progesterone-mediated oocyte maturation
Full description or abstract Xenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division cycles and maturation of the oocyte into a mature, fertilizable egg. This process is termed oocyte maturation. The transition is accompanied by an increase in maturation promoting factor (MPF or Cdc2/cyclin B) which precedes germinal vesicle breakdown (GVBD). Most reports point towards the Mos-MEK1-ERK2 pathway and the polo-like kinase/CDC25 pathway as responsible for the activation of MPF in meiosis, most likely triggered by a decrease in cAMP.
Collection C2: curated gene sets
      CP:KEGG: KEGG gene sets
Source publication  
Exact source hsa04914
Related gene sets  
External links http://www.genome.jp/kegg/pathway/hsa/hsa04914.html
Organism Homo sapiens
Contributed by KEGG (Kyoto Encyclopedia of Genes and Genomes)
Source platform EntrezGeneIds
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Compendia expression profiles Human tissue compendium (Novartis)
NCI-60 cell lines (National Cancer Institute)
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