Gene Set: KIM_GASTRIC_CANCER_CHEMOSENSITIVITY

Standard name KIM_GASTRIC_CANCER_CHEMOSENSITIVITY
Systematic name M14702
Brief description Genes up-regulated in gastric cancer patients refractory to chemotherapy treatment with 5-fluorouracil and cisplatin [PubChem=3385;2767] compared to the sensitive state.
Full description or abstract The mechanisms of intrinsic and/or acquired anti-cancer drug resistance have been described in in vitro resistance models, but the clinical relevance has remained undefined. We undertook a prospective study to identify correlations between gene expression and clinical resistance to 5-FU/cisplatin. We compared expression profiles from gastric cancer endoscopic biopsy specimens obtained at a chemosensitive state (partial remission after 5-FU/cisplatin) with those obtained at a refractory state (disease progression), using Affymetrix oligonucleotide microarray technology (U133A). Using 119 discriminating probes and a cross-validation approach, we were able to correctly identify the chemo-responsiveness of 7 pairs of training samples and 1 independent test pair. These exploratory data demonstrate that the gene expression profiles differ between chemosensitive and refractory state gastric cancer biopsy samples.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 15033468   Authors: Kim HK,Choi IJ,Kim HS,Kim JH,Kim E,Park IS,Chun JH,Kim IH,Kim IJ,Kang HC,Park JH,Bae JM,Lee JS,Park JG
Exact source Fig 4A
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Organism Homo sapiens
Contributed by John Newman (University of Washington)
Source platform HG-U133A
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Compendia expression profiles Human tissue compendium (Novartis)
NCI-60 cell lines (National Cancer Institute)
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Version history 3.0: Renamed from REFRACTORY_GASTRIC_UP

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