Gene Set: KIM_GERMINAL_CENTER_T_HELPER_DN

Standard name KIM_GERMINAL_CENTER_T_HELPER_DN
Systematic name M1408
Brief description Genes down-regulated in germinal center T helper cells compared to other CD4+ [GeneID=920] T lymphocyte types.
Full description or abstract Gene expression profiling was used to compare the gene expression patterns of human germinal center (GC) T helper (Th) cells with other CD4+ T-cell subsets (naive, central, and effector memory T cells). GC-Th cells, specifically localized in germinal centers to help B cells, are distantly related to central and effector memory T cells in global gene expression profiles. GC-Th cells displayed substantial differences in mRNA for adhesion molecules, chemoattractant receptors, and cytokines compared with other populations. Distinct expression of transcriptional factors by GC-Th cells is consistent with the hypothesis that they may be different from other T cells in cell lineage. Interestingly, CXCL13, a critical chemokine for B-cell entry to lymphoid follicles, is one of the most highly up-regulated genes in GC-Th cells. GC-Th cells (but not other T cells) produce and secrete large amounts of functional CXCL13 upon T-cell receptor activation, a process that is dependent on costimulation, requires translation and transcription, and is dramatically enhanced by activation in the presence of GC-B cells. This study revealed for the first time the unique gene expression program of GC-Th cells.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 15213097   Authors: Kim CH,Lim HW,Kim JR,Rott L,Hillsamer P,Butcher EC
Exact source Table 2S
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Organism Homo sapiens
Contributed by Kate Stafford (Broad Institute)
Source platform SEQ_ACCESSION
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Compendia expression profiles Human tissue compendium (Novartis)
NCI-60 cell lines (National Cancer Institute)
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Version history 3.1: First introduced

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