Gene Set: LIAN_NEUTROPHIL_GRANULE_CONSTITUENTS

Standard name LIAN_NEUTROPHIL_GRANULE_CONSTITUENTS
Systematic name M1478
Brief description Granule constituents expressed during mouse promyelocytic cell line differentiation to neutrophils.
Full description or abstract Although the mature neutrophil is one of the better characterized mammalian cell types, the mechanisms of myeloid differentiation are incompletely understood at the molecular level. A mouse promyelocytic cell line (MPRO), derived from murine bone marrow cells and arrested developmentally by a dominant-negative retinoic acid receptor, morphologically differentiates to mature neutrophils in the presence of 10 microM retinoic acid. An extensive catalog was prepared of the gene expression changes that occur during morphologic maturation. To do this, 3'-end differential display, oligonucleotide chip array hybridization, and 2-dimensional protein electrophoresis were used. A large number of genes whose mRNA levels are modulated during differentiation of MPRO cells were identified. The results suggest the involvement of several transcription regulatory factors not previously implicated in this process, but they also emphasize the importance of events other than the production of new transcription factors. Furthermore, gene expression patterns were compared at the level of mRNA and protein, and the correlation between 2 parameters was studied. (Blood. 2001;98:513-524)
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 11468144   Authors: Lian Z,Wang L,Yamaga S,Bonds W,Beazer-Barclay Y,Kluger Y,Gerstein M,Newburger PE,Berliner N,Weissman SM
Exact source Table 4
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Organism Mus musculus
Contributed by Kevin Vogelsang (Broad Institute)
Source platform Mu11KsubA
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Compendia expression profiles Human tissue compendium (Novartis)
NCI-60 cell lines (National Cancer Institute)
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Version history 3.1: First introduced

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