Gene Set: LUI_THYROID_CANCER_PAX8_PPARG_DN

Standard name LUI_THYROID_CANCER_PAX8_PPARG_DN
Systematic name M4902
Brief description Top down-regulated genes distinguishing between follicular thyroid carcinoma (FTC) samples by the presence or absence of the PAX8-PPARG [GeneID=7849;5468] fusion protein.
Full description or abstract The demonstration of the PAX8-PPAR(gamma) fusion oncogene in a subset of follicular thyroid tumors provides a new and promising starting point to dissect the molecular genetic events involved in the development of this tumor form. In the present study, we compared the gene expression profiles of follicular thyroid carcinomas (FTCs) bearing a PAX8-PPAR(gamma) fusion against FTCs that lack this fusion. Using unsupervised clustering and multidimensional scaling analyses, we show that FTCs possessing a PAX8-PPAR(gamma) fusion have a highly uniform and distinct gene expression signature that clearly distinguishes them from FTCs without the fusion. The PAX8-PPAR(gamma)(+) FTCs grouped in a defined cluster, where highly ranked genes were mostly associated with signal transduction, cell growth and translation control. Notably, a large number of ribosomal protein and translation-associated genes were concurrently underexpressed in the FTCs with the fusion. Taken together, our findings further support that follicular carcinomas with a PAX8-PPAR(gamma) rearrangement constitute a distinct biological entity. The current data represent one step to elucidate the molecular pathways in the development of FTCs with the specific PAX8-PPAR(gamma) fusion.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 15608688   Authors: Lui WO,Foukakis T,Lidn J,Thoppe SR,Dwight T,Hg A,Zedenius J,Wallin G,Reimers M,Larsson C
Exact source Figure 3: blue in PAX8-PPARg(-)
Related gene sets (show 7 additional gene sets from the source publication)

(show 4 gene sets from the same authors)
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Organism Homo sapiens
Contributed by Leona Saunders (Broad Institute)
Source platform HG_U95Av2
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Compendia expression profiles Human tissue compendium (Novartis)
NCI-60 cell lines (National Cancer Institute)
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Version history 3.0: First introduced

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