Gene Set: MARSON_FOXP3_TARGETS_DN

Standard name MARSON_FOXP3_TARGETS_DN
Systematic name M2160
Brief description Genes down-regulated by FOXP3 [GeneID=50943] in both ex vivo and hybridoma cells.
Full description or abstract Foxp3+CD4+CD25+ regulatory T (T(reg)) cells are essential for the prevention of autoimmunity. T(reg) cells have an attenuated cytokine response to T-cell receptor stimulation, and can suppress the proliferation and effector function of neighbouring T cells. The forkhead transcription factor Foxp3 (forkhead box P3) is selectively expressed in T(reg) cells, is required for T(reg) development and function, and is sufficient to induce a T(reg) phenotype in conventional CD4+CD25- T cells. Mutations in Foxp3 cause severe, multi-organ autoimmunity in both human and mouse. FOXP3 can cooperate in a DNA-binding complex with NFAT (nuclear factor of activated T cells) to regulate the transcription of several known target genes. However, the global set of genes regulated directly by Foxp3 is not known and consequently, how this transcription factor controls the gene expression programme for T(reg) function is not understood. Here we identify Foxp3 target genes and report that many of these are key modulators of T-cell activation and function. Remarkably, the predominant, although not exclusive, effect of Foxp3 occupancy is to suppress the activation of target genes on T-cell stimulation. Foxp3 suppression of its targets appears to be crucial for the normal function of T(reg) cells, because overactive variants of some target genes are known to be associated with autoimmune disease.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 17237765   Authors: Marson A,Kretschmer K,Frampton GM,Jacobsen ES,Polansky JK,MacIsaac KD,Levine SS,Fraenkel E,von Boehmer H,Young RA
Exact source Table 10S: Ex vivo < 0 & hybridoma < 0
Related gene sets (show 7 additional gene sets from the source publication)

(show 65 gene sets from the same authors)
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Organism Mus musculus
Contributed by Arthur Liberzon (Broad Institute)
Source platform Mouse430_2
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Compendia expression profiles Human tissue compendium (Novartis)
NCI-60 cell lines (National Cancer Institute)
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Version history 3.0: First introduced

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