Gene Set: MENSE_HYPOXIA_UP

Standard name MENSE_HYPOXIA_UP
Systematic name M11033
Brief description Hypoxia response genes up-regulated in both astrocytes and HeLa cell line.
Full description or abstract Oxygen is vital for the development and survival of mammals. In response to hypoxia, the brain initiates numerous adaptive responses at the organ level as well as at the molecular and cellular levels, including the alteration of gene expression. Astrocytes play critical roles in the proper functioning of the brain; thus the manner in which astrocytes respond to hypoxia is likely important in determining the outcome of brain hypoxia. Here, we used microarray gene expression profiling and data-analysis algorithms to identify and analyze hypoxia-responsive genes in primary human astrocytes. We also compared gene expression patterns in astrocytes with those in human HeLa cells and pulmonary artery endothelial cells (ECs). Remarkably, in astrocytes, five times as many genes were induced as suppressed, whereas in HeLa and pulmonary ECs, as many as or more genes were suppressed than induced. More genes encoding hypoxia-inducible functions, such as glycolytic enzymes and angiogenic growth factors, were strongly induced in astrocytes compared with HeLa cells. Furthermore, gene ontology and computational algorithms revealed that many target genes of the EGF and insulin signaling pathways and the transcriptional regulators Myc, Jun, and p53 were selectively altered by hypoxia in astrocytes. Indeed, Western blot analysis confirmed that two major signal transducers mediating insulin and EGF action, Akt and MEK1/2, were activated by hypoxia in astrocytes. These results provide a global view of the signaling and regulatory network mediating oxygen regulation in human astrocytes
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 16507782   Authors: Mense SM,Sengupta A,Zhou M,Lan C,Bentsman G,Volsky DJ,Zhang L
Exact source Table 1S: Induced
Related gene sets (show 9 gene sets from the same authors)
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Organism Homo sapiens
Contributed by Kevin Vogelsang (Broad Institute)
Source platform HG-U133_Plus_2
Dataset references (show 3 datasets)
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Compendia expression profiles Human tissue compendium (Novartis)
NCI-60 cell lines (National Cancer Institute)
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Version history 3.0: Renamed from MENSE_HYPOXIA_UP

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