Gene Set: MINGUEZ_LIVER_CANCER_VASCULAR_INVASION_DN

Standard name MINGUEZ_LIVER_CANCER_VASCULAR_INVASION_DN
Systematic name M398
Brief description Genes under-expressed in hepatocellular carcinoma (HCC) with vascular invasion.
Full description or abstract In approximately 70% of patients with hepatocellular carcinoma (HCC) treated by resection or ablation, disease recurs within 5 years. Although gene expression signatures have been associated with outcome, there is no method to predict recurrence based on combined clinical, pathology, and genomic data (from tumor and cirrhotic tissue). We evaluated gene expression signatures associated with outcome in a large cohort of patients with early stage (Barcelona-Clinic Liver Cancer 0/A), single-nodule HCC and heterogeneity of signatures within tumor tissues.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 21320499   Authors: Villanueva A,Hoshida Y,Battiston C,Tovar V,Sia D,Alsinet C,Cornella H,Liberzon A,Kobayashi M,Kumada H,Thung SN,Bruix J,Newell P,April C,Fan JB,Roayaie S,Mazzaferro V,Schwartz ME,Llovet JM
Exact source Table 2: Signal-to-noise ratio < 0
Related gene sets (show 11 additional gene sets from the source publication)

(show 25 gene sets from the same authors)
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Organism Homo sapiens
Contributed by Yujin Hoshida (Broad Institute)
Source platform EntrezGeneIds
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Compendia expression profiles Human tissue compendium (Novartis)
NCI-60 cell lines (National Cancer Institute)
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Version history 6.2: First introduced

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