Gene Set: PETRETTO_CARDIAC_HYPERTROPHY

Standard name PETRETTO_CARDIAC_HYPERTROPHY
Systematic name M14043
Brief description Genes that correlated most highly with left ventricular mass (LVM) index.
Full description or abstract Left ventricular mass (LVM) and cardiac gene expression are complex traits regulated by factors both intrinsic and extrinsic to the heart. To dissect the major determinants of LVM, we combined expression quantitative trait locus1 and quantitative trait transcript (QTT) analyses of the cardiac transcriptome in the rat. Using these methods and in vitro functional assays, we identified osteoglycin (Ogn) as a major candidate regulator of rat LVM, with increased Ogn protein expression associated with elevated LVM. We also applied genome-wide QTT analysis to the human heart and observed that, out of 22,000 transcripts, OGN transcript abundance had the highest correlation with LVM. We further confirmed a role for Ogn in the in vivo regulation of LVM in Ogn knockout mice. Taken together, these data implicate Ogn as a key regulator of LVM in rats, mice and humans, and suggest that Ogn modifies the hypertrophic response to extrinsic factors such as hypertension and aortic stenosis.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 18443592   Authors: Petretto E,Sarwar R,Grieve I,Lu H,Kumaran MK,Muckett PJ,Mangion J,Schroen B,Benson M,Punjabi PP,Prasad SK,Pennell DJ,Kiesewetter C,Tasheva ES,Corpuz LM,Webb MD,Conrad GW,Kurtz TW,Kren V,Fischer J,Hubner N,Pinto YM,Pravenec M,Aitman TJ,Cook SA
Exact source Table 1
Related gene sets (show 6 additional gene sets from the source publication)
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Organism Homo sapiens
Contributed by Jessica Robertson (Broad Institute)
Source platform HG-U133A
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Compendia expression profiles Human tissue compendium (Novartis)
NCI-60 cell lines (National Cancer Institute)
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Version history 3.0: First introduced

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