Human Gene Set: PETRETTO_LEFT_VENTRICLE_MASS_QTL_CIS_DN


Standard name PETRETTO_LEFT_VENTRICLE_MASS_QTL_CIS_DN
Systematic name M1382
Brief description Down-regulated cis-regulated expression quantitative loci (cis-eQTL) in the heart that were identified as candidate genes for the regulation of left ventricle mass (LVM).
Full description or abstract Left ventricular mass (LVM) and cardiac gene expression are complex traits regulated by factors both intrinsic and extrinsic to the heart. To dissect the major determinants of LVM, we combined expression quantitative trait locus1 and quantitative trait transcript (QTT) analyses of the cardiac transcriptome in the rat. Using these methods and in vitro functional assays, we identified osteoglycin (Ogn) as a major candidate regulator of rat LVM, with increased Ogn protein expression associated with elevated LVM. We also applied genome-wide QTT analysis to the human heart and observed that, out of 22,000 transcripts, OGN transcript abundance had the highest correlation with LVM. We further confirmed a role for Ogn in the in vivo regulation of LVM in Ogn knockout mice. Taken together, these data implicate Ogn as a key regulator of LVM in rats, mice and humans, and suggest that Ogn modifies the hypertrophic response to extrinsic factors such as hypertension and aortic stenosis.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 18443592   Authors: Petretto E,Sarwar R,Grieve I,Lu H,Kumaran MK,Muckett PJ,Mangion J,Schroen B,Benson M,Punjabi PP,Prasad SK,Pennell DJ,Kiesewetter C,Tasheva ES,Corpuz LM,Webb MD,Conrad GW,Kurtz TW,Kren V,Fischer J,Hubner N,Pinto YM,Pravenec M,Aitman TJ,Cook SA
Exact source Table 5S
Related gene sets (show 6 additional gene sets from the source publication)
External links
Filtered by similarity ?
Source species Rattus norvegicus
Contributed by Jessica Robertson (MSigDB Team)
Source platform or
identifier namespace
AFFY_Rat230
Dataset references (show 1 datasets)
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? NG-CHM interactive heatmaps
(Please note that clustering takes a few seconds)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)

Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 10 genes
Gene families ? Categorize these 10 genes by gene family
Show members (show 14 source identifiers mapped to 10 genes)
Version history 3.1: First introduced

See MSigDB license terms here. Please note that certain gene sets have special access terms.