Gene Set: RAMALHO_STEMNESS_UP

Standard name RAMALHO_STEMNESS_UP
Systematic name M9473
Brief description Genes enriched in embryonic, neural and hematopoietic stem cells.
Full description or abstract The transcriptional profiles of mouse embryonic, neural, and hematopoietic stem cells were compared to define a genetic program for stem cells. A total of 216 genes are enriched in all three types of stem cells, and several of these genes are clustered in the genome. When compared to differentiated cell types, stem cells express a significantly higher number of genes (represented by expressed sequence tags) whose functions are unknown. Embryonic and neural stem cells have many similarities at the transcriptional level. These results provide a foundation for a more detailed understanding of stem cell biology.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 12228720   Authors: Ramalho-Santos M,Yoon S,Matsuzaki Y,Mulligan RC,Melton DA
Exact source Suppl. Database
Related gene sets (show 1 additional gene sets from the source publication)

(show 3 gene sets from the same authors)
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Organism Mus musculus
Contributed by John Newman (University of Washington)
Source platform MG_U74Av2
Dataset references  
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Compendia expression profiles Human tissue compendium (Novartis)
NCI-60 cell lines (National Cancer Institute)
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Version history 3.0: Renamed from STEMCELL_COMMON_UP

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