Gene Set: RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_UP

Standard name RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_UP
Systematic name M12636
Brief description Genes up-regulated in peripheral blood monocytes by CSF2RB (GM-CSF) and IL4 [GeneID=1437;3565].
Full description or abstract Several hematopoietic growth factors, including interleukin-10 (IL-10) and transforming growth factor-beta1 (TGF-beta1), promote the differentiation of tolerogenic dendritic cells (DCs). Hepatocyte growth factor (HGF) is a pleiotropic cytokine whose effects on human DC differentiation and function have not been investigated. Monocytes cultured with HGF (HGFMo) differentiated into accessory cells with DC-like morphology, released low amounts of IL-12p70 and up-regulated IL-10 both at the mRNA and at the protein level. Upon activation with HGFMo, allogeneic CD4+CD25- T cells expressed the T regulatory (Treg)-associated transcription factor FoxP3, proliferated poorly, and released high levels of IL-10. Interestingly, blockade of surface immunoglobulin-like transcript 3 (ILT3) on HGFMo or neutralization of secreted IL-10 translated into partial restoration of T-cell proliferation. Secondary stimulation of HGFMo-primed CD4+ T cells with immunogenic DCs differentiated with granulocyte-macrophage colony-stimulating factor (GM-CSF) and IL-4 from monocytes of the same donor resulted in measurable T-cell proliferation. HGFMo-primed CD4+ T cells significantly inhibited the proliferation of naive CD4+CD25- T cells in a cell-contact-dependent manner. Finally, DNA microarray analysis revealed a unique gene-expression profile of HGF-activated monocytes. Collectively, our findings point to a novel role for HGF in the regulation of monocyte/DC functions that might be exploited therapeutically.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 16527888   Authors: Rutella S,Bonanno G,Procoli A,Mariotti A,de Ritis DG,Curti A,Danese S,Pessina G,Pandolfi S,Natoni F,Di Febo A,Scambia G,Manfredini R,Salati S,Ferrari S,Pierelli L,Leone G,Lemoli RM
Exact source Table 1S: GM4-DCs vs Ctrl FC >= 1
Related gene sets (show 5 additional gene sets from the source publication)

(show 10 gene sets from the same authors)
External links  
Organism Homo sapiens
Contributed by Arthur Liberzon (Broad Institute)
Source platform HG-U133A
Dataset references  
Download gene set format: grp | text | gmt | gmx | xml
Compute overlaps (show collections to investigate for overlap with this gene set)
Compendia expression profiles Human tissue compendium (Novartis)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 338 genes
Gene families Categorize these 338 genes by gene family
Show members (show 346 members mapped to 338 genes)
Version history  

See MSigDB license terms here. Please note that certain gene sets have special access terms.