Gene Set: SAFFORD_T_LYMPHOCYTE_ANERGY

Standard name SAFFORD_T_LYMPHOCYTE_ANERGY
Systematic name M1644
Brief description Genes up-regulated in anergic mouse T helper cells (A.E7), versus non-anergic stimulated controls
Full description or abstract T cell receptor engagement in the absence of proper accessory signals leads to T cell anergy. E3 ligases are involved in maintaining the anergic state. However, the specific molecules responsible for the induction of anergy have yet to be elucidated. Using microarray analysis we have identified here early growth response gene 2 (Egr-2) and Egr-3 as key negative regulators of T cell activation. Overexpression of Egr2 and Egr3 was associated with an increase in the E3 ubiquitin ligase Cbl-b and inhibition of T cell activation. Conversely, T cells from Egr3(-/-) mice had lower expression of Cbl-b and were resistant to in vivo peptide-induced tolerance. These data support the idea that Egr-2 and Egr-3 are involved in promoting a T cell receptor-induced negative regulatory genetic program.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 15834410   Authors: Safford M,Collins S,Lutz MA,Allen A,Huang CT,Kowalski J,Blackford A,Horton MR,Drake C,Schwartz RH,Powell JD
Exact source Table 1
Related gene sets (show 4 gene sets from the same authors)
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Organism Mus musculus
Contributed by John Newman (University of Washington)
Source platform MOUSE_GENE_SYMBOL
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Compendia expression profiles Human tissue compendium (Novartis)
NCI-60 cell lines (National Cancer Institute)
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Version history 3.1: First introduced

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