Gene Set: SINGH_KRAS_DEPENDENCY_SIGNATURE_

Standard name SINGH_KRAS_DEPENDENCY_SIGNATURE_
Systematic name M2851
Brief description Genes defining the KRAS [GeneID=3845] dependency signature.
Full description or abstract K-ras mutations occur frequently in epithelial cancers. Using short hairpin RNAs to deplete K-Ras in lung and pancreatic cancer cell lines harboring K-ras mutations, two classes were identified-lines that do or do not require K-Ras to maintain viability. Comparing these two classes of cancer cells revealed a gene expression signature in K-Ras-dependent cells, associated with a well-differentiated epithelial phenotype, which was also seen in primary tumors. Several of these genes encode pharmacologically tractable proteins, such as Syk and Ron kinases and integrin beta6, depletion of which induces epithelial-mesenchymal transformation (EMT) and apoptosis specifically in K-Ras-dependent cells. These findings indicate that epithelial differentiation and tumor cell viability are associated, and that EMT regulators in K-Ras-addicted cancers represent candidate therapeutic targets.
Collection C6: oncogenic signatures
Source publication Pubmed 19477428   Authors: Singh A,Greninger P,Rhodes D,Koopman L,Violette S,Bardeesy N,Settleman J
Exact source Fig. 5B
Related gene sets (show 9 gene sets from the same authors)
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Organism Homo sapiens
Contributed by Pablo Tamayo (Broad Institute)
Source platform HUMAN_GENE_SYMBOL
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Compendia expression profiles Human tissue compendium (Novartis)
NCI-60 cell lines (National Cancer Institute)
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