Systematic name M2104
Brief description Genes repressed in SKBR3 cells (breast cancer) by 25-hydroxyvitamin D3 [PubChem=1593].
Full description or abstract The p53 gene is mutated in many human tumors. Cells of such tumors often contain abundant mutant p53 (mutp53) protein, which may contribute actively to tumor progression via a gain-of-function mechanism. We applied ChIP-on-chip analysis and identified the vitamin D receptor (VDR) response element as overrepresented in promoter sequences bound by mutp53. We report that mutp53 can interact functionally and physically with VDR. Mutp53 is recruited to VDR-regulated genes and modulates their expression, augmenting the transactivation of some genes and relieving the repression of others. Furthermore, mutp53 increases the nuclear accumulation of VDR. Importantly, mutp53 converts vitamin D into an antiapoptotic agent. Thus, p53 status can determine the biological impact of vitamin D on tumor cells.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 20227041   Authors: Stambolsky P,Tabach Y,Fontemaggi G,Weisz L,Maor-Aloni R,Siegfried Z,Shiff I,Kogan I,Shay M,Kalo E,Blandino G,Simon I,Oren M,Rotter V
Exact source Table 2S: Genes repressed by vitamin D3
Related gene sets (show 4 additional gene sets from the source publication)

(show 16 gene sets from the same authors)
External links  
Organism Homo sapiens
Contributed by Arthur Liberzon (Broad Institute)
Source platform HUMAN_GENE_SYMBOL
Dataset references (show 1 datasets)
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Compendia expression profiles Human tissue compendium (Novartis)
NCI-60 cell lines (National Cancer Institute)
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Version history 3.1: First introduced

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