Gene Set: TONG_INTERACT_WITH_PTTG1

Standard name TONG_INTERACT_WITH_PTTG1
Systematic name M3844
Brief description Proteins that interact with PTTG1 [GeneID=9232], based on protein array.
Full description or abstract Pituitary tumor transforming gene 1 (PTTG1), a transforming gene highly expressed in several cancers, is a mammalian securin protein regulating both G1/S and G2/M phases. Using protein array screening, we showed PTTG1 interacting with Aurora kinase A (Aurora-A), and confirmed the interaction using co-immunoprecipitation, His-tagged pull-down assays and intracellular immunofluorescence colocalization. PTTG1 transfection into HCT116 cells prevented Aurora-A T288 autophosphorylation, inhibited phosphorylation of the histone H3 Aurora-A substrate and resulted in abnormally condensed chromatin. PTTG1-null cell proliferation was more sensitive to Aurora-A knock down and to Aurora kinase Inhibitor III treatment. The results indicate that PTTG1 and Aurora-A interact to regulate cellular responses to anti-neoplastic drugs. PTTG1 knockdown is therefore a potential approach to improve the efficacy of tumor Aurora kinase inhibitors.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 18663361   Authors: Tong Y,Ben-Shlomo A,Zhou C,Wawrowsky K,Melmed S
Exact source Table 1S
Related gene sets (show 4 gene sets from the same authors)
External links  
Organism Homo sapiens
Contributed by Jessica Robertson (Broad Institute)
Source platform SEQ_ACCESSION
Dataset references  
Download gene set format: grp | text | gmt | gmx | xml
Compute overlaps (show collections to investigate for overlap with this gene set)
Compendia expression profiles Human tissue compendium (Novartis)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 57 genes
Gene families Categorize these 57 genes by gene family
Show members (show 59 members mapped to 57 genes)
Version history 3.0: First introduced

See MSigDB license terms here. Please note that certain gene sets have special access terms.