Gene Set: VANOEVELEN_MYOGENESIS_SIN3A_TARGETS

Standard name VANOEVELEN_MYOGENESIS_SIN3A_TARGETS
Systematic name M2524
Brief description Loci bound exclusively by SIN3A [GeneID=25942] in myotubules.
Full description or abstract The highly related mammalian Sin3A and Sin3B proteins provide a versatile platform for chromatin-modifying activities. Sin3-containing complexes play a role in gene repression through deacetylation of nucleosomes. Here, we explore a role for Sin3 in myogenesis by examining the phenotypes resulting from acute somatic deletion of both isoforms in vivo and from primary myotubes in vitro. Myotubes ablated for Sin3A alone, but not Sin3B, displayed gross defects in sarcomere structure that were considerably enhanced upon simultaneous ablation of both isoforms. Massively parallel sequencing of Sin3A- and Sin3B-bound genomic loci revealed a subset of target genes directly involved in sarcomere function that are positively regulated by Sin3A and Sin3B proteins. Both proteins were coordinately recruited to a substantial number of genes. Interestingly, depletion of Sin3B led to compensatory increases in Sin3A recruitment at certain target loci, but Sin3B was never found to compensate for Sin3A loss. Thus, our analyses describe a novel transcriptional role for Sin3A and Sin3B proteins associated with maintenance of differentiated muscle cells.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 20956564   Authors: van Oevelen C,Bowman C,Pellegrino J,Asp P,Cheng J,Parisi F,Micsinai M,Kluger Y,Chu A,Blais A,David G,Dynlacht BD
Exact source Table 1S: Sin3A targets only
Related gene sets (show 2 gene sets from the same authors)
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Organism Mus musculus
Contributed by Arthur Liberzon (Broad Institute)
Source platform MOUSE_GENE_SYMBOL
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Compendia expression profiles Human tissue compendium (Novartis)
NCI-60 cell lines (National Cancer Institute)
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Version history 3.1: First introduced

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