Systematic name M16922
Brief description Genes specifically expressed in samples from patients with pediatric acute myeloid leukemia (AML) bearing t(9;11) translocation.
Full description or abstract Most patients with acute myeloid leukemia (AML) enter complete remission (CR) after treatment with chemotherapy, but a large number of them experience relapse with resistant disease. To identify genes that are associated with their prognoses, we analyzed gene expression in 54 pediatric patients with AML using an oligonucleotide microarray that contained 12 566 probe sets. A supervised approach using the Student t test selected a prognostic set of 35 genes, some of which are associated with the regulation of cell cycle and apoptosis. Most of these genes had not previously been reported to be associated with prognosis and were not correlated with morphologically classified French-American-British (FAB) subtypes or with karyotypes. These results indicate the existence of prognosis-associated genes that are independent of cell lineage and cytogenetic abnormalities, and they can provide therapeutic direction for individual risk-adapted therapy for pediatric AML patients.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 12738660   Authors: Yagi T,Morimoto A,Eguchi M,Hibi S,Sako M,Ishii E,Mizutani S,Imashuku S,Ohki M,Ichikawa H
Exact source Table 4S: t(9;11)-specific probe sets (144 probe sets)
Related gene sets (show 6 additional gene sets from the source publication)

(show 103 gene sets from the same authors)
External links  
Organism Homo sapiens
Contributed by Arthur Liberzon (Broad Institute)
Source platform HG_U95Av2
Dataset references (show 1 datasets)
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Compendia expression profiles Human tissue compendium (Novartis)
NCI-60 cell lines (National Cancer Institute)
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Version history 3.0: First introduced

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