Systematic name M1679
Brief description Genes up-regulated in CD-1 compared to CD-2 cluster of multiple myeloma samples.
Full description or abstract To better define the molecular basis of multiple myeloma (MM), we performed unsupervised hierarchic clustering of mRNA expression profiles in CD138-enriched plasma cells from 414 newly diagnosed patients who went on to receive high-dose therapy and tandem stem cell transplants. Seven disease subtypes were validated that were strongly influenced by known genetic lesions, such as c-MAF- and MAFB-, CCND1- and CCND3-, and MMSET-activating translocations and hyperdiploidy. Indicative of the deregulation of common pathways by gene orthologs, common gene signatures were observed in cases with c-MAF and MAFB activation and CCND1 and CCND3 activation, the latter consisting of 2 subgroups, one characterized by expression of the early B-cell markers CD20 and PAX5. A low incidence of focal bone disease distinguished one and increased expression of proliferation-associated genes of another novel subgroup. Comprising varying fractions of each of the other 6 subgroups, the proliferation subgroup dominated at relapse, suggesting that this signature is linked to disease progression. Proliferation and MMSET-spike groups were characterized by significant overexpression of genes mapping to chromosome 1q, and both exhibited a poor prognosis relative to the other groups. A subset of cases with a predominating myeloid gene expression signature, excluded from the profiling analyses, had more favorable baseline characteristics and superior prognosis to those lacking this signature.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 16728703   Authors: Zhan F,Huang Y,Colla S,Stewart JP,Hanamura I,Gupta S,Epstein J,Yaccoby S,Sawyer J,Burington B,Anaissie E,Hollmig K,Pineda-Roman M,Tricot G,van Rhee F,Walker R,Zangari M,Crowley J,Barlogie B,Shaughnessy JD Jr
Exact source Table 6S: SAM Score > 0
Related gene sets (show 17 additional gene sets from the source publication)

(show 36 gene sets from the same authors)
External links  
Organism Homo sapiens
Contributed by Kevin Vogelsang (Broad Institute)
Source platform HG-U133_Plus_2
Dataset references (show 1 datasets)
Download gene set format: grp | text | gmt | gmx | xml
Compute overlaps (show collections to investigate for overlap with this gene set)
Compendia expression profiles Human tissue compendium (Novartis)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 66 genes
Gene families Categorize these 66 genes by gene family
Show members (show 69 members mapped to 66 genes)
Version history 3.0: Renamed from ZHAN_MM_MOLECULAR_CLASSI_UP

See MSigDB license terms here. Please note that certain gene sets have special access terms.