Gene Set: AMIT_EGF_RESPONSE_20_MCF10A

Standard name AMIT_EGF_RESPONSE_20_MCF10A
Systematic name M4625
Brief description Genes whose expression peaked at 20 min after stimulation of MCF10A cells with EGF [GeneID=1950].
Full description or abstract Signaling pathways invoke interplays between forward signaling and feedback to drive robust cellular response. In this study, we address the dynamics of growth factor signaling through profiling of protein phosphorylation and gene expression, demonstrating the presence of a kinetically defined cluster of delayed early genes that function to attenuate the early events of growth factor signaling. Using epidermal growth factor receptor signaling as the major model system and concentrating on regulation of transcription and mRNA stability, we demonstrate that a number of genes within the delayed early gene cluster function as feedback regulators of immediate early genes. Consistent with their role in negative regulation of cell signaling, genes within this cluster are downregulated in diverse tumor types, in correlation with clinical outcome. More generally, our study proposes a mechanistic description of the cellular response to growth factors by defining architectural motifs that underlie the function of signaling networks.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 17322878   Authors: Amit I,Citri A,Shay T,Lu Y,Katz M,Zhang F,Tarcic G,Siwak D,Lahad J,Jacob-Hirsch J,Amariglio N,Vaisman N,Segal E,Rechavi G,Alon U,Mills GB,Domany E,Yarden Y
Exact source Table 1S: Part-5 EGF peak 20 min
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Organism Homo sapiens
Contributed by Leona Saunders (MSigDB Team)
Source platform HG-U133A
Dataset references (show 3 datasets)
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Compendia expression profiles Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
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Version history 3.0: First introduced

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