Gene Set: GSE18893_TCONV_VS_TREG_24H_TNF_STIM_DN

Standard name GSE18893_TCONV_VS_TREG_24H_TNF_STIM_DN
Systematic name M7291
Brief description Genes down-regulated in lymphocytes treated with TNF [GeneID=7124] for 24h: T conv versus T reg cells.
Full description or abstract Here we show that tumor necrosis factor (TNF) induced in human T-regulatory cells (Treg), as compared to conventional T cells (Tcon), a transcription program highly enriched for typical NF-?B target genes, such as: the cytokines LTA and TNF; the TNF-receptor super family members FAS, 4-1BB and OX-40; various anti-apoptotic genes; and other important immune-response genes. As an initial approach to examine the cellular program induced by TNF in Tregs versus Tcon cells, we employed microarray gene expression analysis at 2 and 24 hrs following TNF treatment.
Collection C7: immunologic signatures
Source publication Pubmed 20181891   Authors: Nagar M,Jacob-Hirsch J,Vernitsky H,Berkun Y,Ben-Horin S,Amariglio N,Bank I,Kloog Y,Rechavi G,Goldstein I
Exact source GSE18893_1280_200_DN
Related gene sets (show 15 additional gene sets from the source publication)

(show 65 gene sets from the same authors)
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Organism Homo sapiens
Contributed by Jernej Godec (Dana-Farber Cancer Institute)
Source platform HUMAN_GENE_SYMBOL
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Compendia expression profiles Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
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Version history 5.1: First introduced

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