Gene Set: RODWELL_AGING_KIDNEY_DN

Standard name RODWELL_AGING_KIDNEY_DN
Systematic name M5408
Brief description Genes whose expression decreases with age in normal kidney.
Full description or abstract In this study, we found 985 genes that change expression in the cortex and the medulla of the kidney with age. Some of the genes whose transcripts increase in abundance with age are known to be specifically expressed in immune cells, suggesting that immune surveillance or inflammation increases with age. The age-regulated genes show a similar aging profile in the cortex and the medulla, suggesting a common underlying mechanism for aging. Expression profiles of these age-regulated genes mark not only age, but also the relative health and physiology of the kidney in older individuals. Finally, the set of aging-regulated kidney genes suggests specific mechanisms and pathways that may play a role in kidney degeneration with age.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 15562319   Authors: Rodwell GE,Sonu R,Zahn JM,Lund J,Wilhelmy J,Wang L,Xiao W,Mindrinos M,Crane E,Segal E,Myers BD,Brooks JD,Davis RW,Higgins J,Owen AB,Kim SK
Exact source Table 3S: coefficient < 0
Related gene sets (show 3 additional gene sets from the source publication)

(show 80 gene sets from the same authors)
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Organism Homo sapiens
Contributed by John Newman (University of Washington)
Source platform HG-U133A
Dataset references (show 1 datasets)
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Compendia expression profiles Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
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Version history 3.0: Renamed from AGEING_KIDNEY_DN

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