Gene Set: WONG_ADULT_TISSUE_STEM_MODULE

Standard name WONG_ADULT_TISSUE_STEM_MODULE
Systematic name M1999
Brief description The 'adult tissue stem' module: genes coordinately up-regulated in a compendium of adult tissue stem cells.
Full description or abstract Self-renewal is a hallmark of stem cells and cancer, but existence of a shared stemness program remains controversial. Here, we construct a gene module map to systematically relate transcriptional programs in embryonic stem cells (ESCs), adult tissue stem cells, and human cancers. This map reveals two predominant gene modules that distinguish ESCs and adult tissue stem cells. The ESC-like transcriptional program is activated in diverse human epithelial cancers and strongly predicts metastasis and death. c-Myc, but not other oncogenes, is sufficient to reactivate the ESC-like program in normal and cancer cells. In primary human keratinocytes transformed by Ras and I kappa B alpha, c-Myc increases the fraction of tumor-initiating cells by 150-fold, enabling tumor formation and serial propagation with as few as 500 cells. c-Myc-enhanced tumor initiation is cell-autonomous and independent of genomic instability. Thus, activation of an ESC-like transcriptional program in differentiated adult cells may induce pathologic self-renewal characteristic of cancer stem cells.
Collection C2: curated gene sets
      CGP: chemical and genetic perturbations
Source publication Pubmed 18397753   Authors: Wong DJ,Liu H,Ridky TW,Cassarino D,Segal E,Chang HY
Exact source Table 4S: Mouse Entrez Gene ID
Related gene sets (show 1 additional gene sets from the source publication)

(show 54 gene sets from the same authors)
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Organism Mus musculus
Contributed by Arthur Liberzon (MSigDB Team)
Source platform EntrezGeneIds
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Compendia expression profiles Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
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Version history 3.1: First introduced

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