Difference between revisions of "Gene Set Pages"

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[http://www.broadinstitute.org/gsea/ GSEA Home] |
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<p class="MsoNormal" style="">Each gene set in the MSigDB (Molecular Signature Database) is fully described by a gene set card. To review the gene set cards, click [http://wwwdev.broad.mit.edu/gsea/msigdb/cards_index.html here]. Or, from within the GSEA application, use the Browse MSigDB page to browse the gene sets and to display their gene set cards.</p>
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[http://www.broadinstitute.org/gsea/downloads.jsp Downloads] |
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<p class="MsoNormal" style="">Each gene set card contains the following information:</p>
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[http://www.broadinstitute.org/gsea/msigdb/ Molecular Signatures Database] |
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<p class="MsoNormal" style=""><strong style="">Standard name</strong>: Gene set name.</p>
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[http://www.broadinstitute.org/cancer/software/gsea/wiki/index.php/Main_Page Documentation] |
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<p class="MsoNormal" style=""><strong style="">Systematic name</strong>: Internal identifier for the gene set, which consists of three parts:<br /></p>
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[http://www.broadinstitute.org/gsea/contact.jsp Contact]
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<p class="MsoNormal" style="">  </p>
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<br>
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<p class="MsoListBullet2"><!--[if !supportLists]--><span style="">▪<span style="font-family: &quot;Times New Roman&quot;; font-style: normal; font-variant: normal; font-weight: normal; font-size: 7pt; line-height: normal; font-size-adjust: none; font-stretch: normal;">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; </span></span><!--[endif]-->Category: Positional (C1), Curated (C2), Motif (C3), or Computed (C4).</p>
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<p>
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<span style="">▪<span style="font-family: &quot;Times New Roman&quot;; font-style: normal; font-variant: normal; font-weight: normal; font-size: 7pt; line-height: normal; font-size-adjust: none; font-stretch: normal;">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; </span></span>Subcategory: for C1, always      Cytogenic; for C2, Animal Model, Clinical, Experimental pertuberation,      Expert curation, Misc, Ontology, Pathway database, or Review paper; for      C3, Representative motifs or Transfac; and for C4, always Neighborhood.
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Each gene set in the MSigDB (Molecular Signature Database) is fully described by a gene set page. From this web site, use the&nbsp; [http://www.broadinstitute.org/gsea/msigdb/ MSigDB page] to find a gene set. Click the gene set name to display its gene set page. Alternatively, from within the GSEA application, use the [http://www.broadinstitute.org/gsea/doc/GSEAUserGuideFrame.html?Browse_MSigDB_Page Browse MSigDB page] to browse gene sets and display gene set pages. </p>
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<p class="MsoListBullet2"><!--[if !supportLists]--><span style="">▪<span style="font-family: &quot;Times New Roman&quot;; font-style: normal; font-variant: normal; font-weight: normal; font-size: 7pt; line-height: normal; font-size-adjust: none; font-stretch: normal;">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; </span></span><!--[endif]-->Number: a unique number with the category:subcategory classification.</p>
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<p>Each gene set page contains the following information:</p>
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<!--[if !supportLists]--><!--[endif]--> <span style=""></span>
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<ul>                </ul>
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<h2>Gene Set Annotations</h2>
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    <!--[if !supportLists]-->
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<dl>
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    <ul>                </ul>
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<dt>Standard name
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        <p class="MsoNormal" style=""><strong style="">Brief description</strong>: A brief description of the gene. This is the description that appears on the Browse MSigDB page of the GSEA application. </p>
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<dd>Gene set name in the database. Gene sets can have their names changed after reviewing or to correct potential errors.
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        <p class="MsoNormal" style=""><strong style="">Category</strong>: </p>
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<dt>Systematic name
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        <p class="MsoNormal" style=""><strong style="">Sub-category</strong>: </p>
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<dd>This serves to uniquely identify a gene set in MSigDB. Unlike standard names, systematic name never changes.
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        <p class="MsoNormal"><strong style="">Full description or Abstract</strong>: A more complete description of the gene set. For example, for gene sets linked to a PubMed entry, this field shows the abstract of that entry.</p>
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<dt> Brief description
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        <p class="MsoNormal"><strong style="">Publication URL</strong>: When available, a link to the source publication. For example, for gene sets linked to a PubMed entry, this is a link to the Entrez record of the source publication. </p>
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<dd>A one sentence description of the gene set to convey "at a glance" information about gene sets.
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        <p class="MsoNormal"><strong style="">External links</strong>: When available, links to external websites that contain more information about the gene set.</p>
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This description appears on the Browse MSigDB page of the GSEA application.
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        <p class="MsoNormal"><strong style="">Keywords &amp; MeSH headings</strong>: Keywords derived from MeSH [http://www.nlm.nih.gov/mesh/MBrowser.html National Library of Medicine] and/or manually entered.</p>
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<dt> Full description or abstract
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        <p class="MsoNormal"><strong style="">Organism</strong>: The organism that the experiment was conducted in (<em>generic</em> for canonical pathways and ontologies).</p>
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<dd>An extensive annotation of the gene set. For gene sets curated from publications, this field contains publication's abstract.
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        <p class="MsoNormal"><strong style="">Contributed by</strong>: Name of the person (or external database; for example, KEGG) who collected the gene set.</p>
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<dt>Collection
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        <p class="MsoNormal"><strong style="">Source platform</strong>: Microarray platform that was used for expression profiling (for example, Affymetrix HU6800). Gene_Symbol is used if the gene set was not tied to a specific experiment (for example, for ontologies or a gene set from a review article).</p>
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<dd>The collection that contains the gene set: Positional (C1), Curated (C2), Motif (C3), Computed (C4), GO (C5) or Oncogenic signatures (C6). In appropriate cases, this will also include the sub-collection hierarchy that contains the gene set. See the [http://www.broadinstitute.org/gsea/msigdb/collections.jsp MSigDB Collections page] for detailed descriptions of each collection.
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        <p class="MsoNormal"><strong style="">Download</strong>: Links to download the gene set in different formats:<br /></p>
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<dt>Source publication
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        <p class="MsoNormal">  </p>
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<dd>When available, a link to the source publication followed by a list of its authors.  
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        <p class="MsoListBullet2"><!--[if !supportLists]--><span style="">▪<span style="font-family: &quot;Times New Roman&quot;; font-style: normal; font-variant: normal; font-weight: normal; font-size: 7pt; line-height: normal; font-size-adjust: none; font-stretch: normal;">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; </span></span><!--[endif]-->grp: lists the genes in the gene set in plain text format</p>
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<dt>Exact source
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        <p class="MsoListBullet2"><!--[if !supportLists]--><span style="">▪<span style="font-family: &quot;Times New Roman&quot;; font-style: normal; font-variant: normal; font-weight: normal; font-size: 7pt; line-height: normal; font-size-adjust: none; font-stretch: normal;">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; </span></span><!--[endif]-->xml: gene set definition formatted with structure annotation </p>
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<dd>For gene sets curated from publications, this field indicates the exact source of a gene set in the publication (e.g., Table 1).
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        <p class="MsoListBullet2"><!--[if !supportLists]--><span style="">▪<span style="font-family: &quot;Times New Roman&quot;; font-style: normal; font-variant: normal; font-weight: normal; font-size: 7pt; line-height: normal; font-size-adjust: none; font-stretch: normal;">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; </span></span><!--[endif]-->map: lists the genes in the gene set with details of the mapping between the originally reported accessions and their HUGO gene symbols</p>
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<dt> Related gene sets
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        <p class="MsoNormal"><strong style="">Genes</strong>: Displays the number of genes (HUGO gene symbols) and accessions (native accessions) in this gene set; if each native accession mapped to a unique HUGO gene symbol, these values are identical. Click the Toggle View link to show/hide the genes in the gene set along with their descriptions and links to external websites for gene-centric information. </p>
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<dd>Other gene sets (if any) from the same publication or from publications shared with at least one of the authors.
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<dt>External links
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<dd>When available, links to external websites with additional information about the gene set.
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<dt>Organism
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<dd>The organism that the experiment was conducted in.
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<dt> Contributed by
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<dd>Name of the person, institution, or external database (such as Reactome) who contributed the gene set.
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<dt> Source platform
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<dd>This field indicates kind of original members as they appeared in the gene set source. For microarray data, this often indicates microarray platform when original members are probe set IDs or other kind of platform specific identifiers. SEQ_ACCESSION indicates NCBI GenBank accession numbers.
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<dt>Dataset references
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<dd>GEO or ArrayExpress links for associated microarray data where appropriate.
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</dl>
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<h2>Gene Set Actions</h2>
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<dl>
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<dt> Download gene set
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<dd>Links to download the gene set in different formats: GRP (group), TXT, GMT, GMX, or XML. For descriptions of each format, see [[Data_formats|Data Formats]].
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<dt>Annotate by computing overlaps
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<dd>Displays the overlap (if any) between this gene set and the gene sets in the selected collection.
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<dt>Compendia expression profiles
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<dd>Produce a heat map showing how genes in this gene set are expressed in the selected compendium dataset.
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<dt>Advanced query
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<dd>Copies the genes in this gene set to the annotations page, where you can modify and/or further explore the gene set.
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<dt>Gene families
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<dd>Displays a functional overview of this gene set by categorizing its members into a small number of gene families, where each gene family describes a collection of proteins that share a common feature such as homology or biochemical activity.
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</dl>
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<h2>Gene Set Members</h2>
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<dl>
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<dt>Show members
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<dd>Toggle the Show (Hide) link show (hide) gene set members followed by links to external websites for gene-centric information.
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</dl>
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<h2>Other</h2>
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<dl>
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<dt>Version history
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<dd>Lists the history of this gene set (when it was introduced and any modifications) where available.
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</dl>

Latest revision as of 02:20, 25 September 2016

GSEA Home | Downloads | Molecular Signatures Database | Documentation | Contact

Each gene set in the MSigDB (Molecular Signature Database) is fully described by a gene set page. From this web site, use the  MSigDB page to find a gene set. Click the gene set name to display its gene set page. Alternatively, from within the GSEA application, use the Browse MSigDB page to browse gene sets and display gene set pages.

Each gene set page contains the following information:

Gene Set Annotations

Standard name
Gene set name in the database. Gene sets can have their names changed after reviewing or to correct potential errors.
Systematic name
This serves to uniquely identify a gene set in MSigDB. Unlike standard names, systematic name never changes.
Brief description
A one sentence description of the gene set to convey "at a glance" information about gene sets. This description appears on the Browse MSigDB page of the GSEA application.
Full description or abstract
An extensive annotation of the gene set. For gene sets curated from publications, this field contains publication's abstract.
Collection
The collection that contains the gene set: Positional (C1), Curated (C2), Motif (C3), Computed (C4), GO (C5) or Oncogenic signatures (C6). In appropriate cases, this will also include the sub-collection hierarchy that contains the gene set. See the MSigDB Collections page for detailed descriptions of each collection.
Source publication
When available, a link to the source publication followed by a list of its authors.
Exact source
For gene sets curated from publications, this field indicates the exact source of a gene set in the publication (e.g., Table 1).
Related gene sets
Other gene sets (if any) from the same publication or from publications shared with at least one of the authors.
External links
When available, links to external websites with additional information about the gene set.
Organism
The organism that the experiment was conducted in.
Contributed by
Name of the person, institution, or external database (such as Reactome) who contributed the gene set.
Source platform
This field indicates kind of original members as they appeared in the gene set source. For microarray data, this often indicates microarray platform when original members are probe set IDs or other kind of platform specific identifiers. SEQ_ACCESSION indicates NCBI GenBank accession numbers.
Dataset references
GEO or ArrayExpress links for associated microarray data where appropriate.

Gene Set Actions

Download gene set
Links to download the gene set in different formats: GRP (group), TXT, GMT, GMX, or XML. For descriptions of each format, see Data Formats.
Annotate by computing overlaps
Displays the overlap (if any) between this gene set and the gene sets in the selected collection.
Compendia expression profiles
Produce a heat map showing how genes in this gene set are expressed in the selected compendium dataset.
Advanced query
Copies the genes in this gene set to the annotations page, where you can modify and/or further explore the gene set.
Gene families
Displays a functional overview of this gene set by categorizing its members into a small number of gene families, where each gene family describes a collection of proteins that share a common feature such as homology or biochemical activity.

Gene Set Members

Show members
Toggle the Show (Hide) link show (hide) gene set members followed by links to external websites for gene-centric information.

Other

Version history
Lists the history of this gene set (when it was introduced and any modifications) where available.
Retrieved from "https://software.broadinstitute.org/cancer/software/gsea/wiki/index.php?title=Gene_Set_Pages&oldid=4014"