MSigDB collections

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This page provides detailed descriptions of all collections of gene sets in MSigDB.

To learn about changes and other information specific for a particular release of MSigDB, please refer to the corresponding Release_Notes.

H: Hallmarks

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C1: positional gene sets

Genes from the same genomic location (chromosome or cytogenetic band) are grouped in a gene set. Cytogenetic annotations are from three sources:

1. Human Genome Organization (HUGO) Gene Nomenclature Committee (HGNC)
2. UniGene
3. Affymetrix microarray annotations

We merged the relevant annotations from these resources and derived a single cytogenetic band location for every gene symbol. These were then grouped into sets. Decimals in cytogenetic bands were ignored. For example, 5q31.1 was considered 5q31. Therefore, genes annotated as 5q31.2 and those annotated as 5q31.3 were both placed in the same set, 5q31.

C2: curated gene sets

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C3: motif gene sets

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C4:computational gene sets

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C5: GO gene sets

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C6: oncogenetic signatures

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C7: immunologic signatures

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